Evolutionary trace is a method that uses a sequence similarity tree of a family of homologous proteins to highlight residues which are statistically likely to be under evolutionary pressure, and therefore of certain functional or structural importance for the family. This enables researchers looking for residues responsible for a detectable phenotype change to focus their search on the individual residues or regions of proteins most likely to produce such a change. Real-valued ET is particularly robust and suitable for making blind predictions about the evolutionary behavior of protein residues. ET ranks residues according to the estimated evolutionary pressure they experience. When the structure is available, ET results may be mapped onto the structure, thus clearly outlining known as well as putative functional parts of the protein surface.
Evolutionary trace report maker pools from different sources information about protein sequence, structure and elementary annotation, and to that background superimposes inference about evolutionary behavior of individual residues, using real-valued evolutionary trace method. As its only input it takes Protein Data Bank identifier or UniProt accession number, and returns a human-readable document in PDF format, supplemented by the original data needed to reproduce the results quoted in the report.
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If you intend to use the Evolutionary Trace Server and viewer as part of a published work, please cite the following papers:
The Evolutionary Trace report_maker is freely available for non-profit use.
For profit use of the Evolutionary Trace report_maker may be arranged by contacting
Mrs. Lisa Beveridge (email@example.com, 713-798-6821) to request a license from Baylor College of Medicine.